High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L (Apiaceae)

Koziol, Ewelina; ŞENOL DENİZ, FATMA; ERDOĞAN ORHAN, İLKAY; Marcourt, Laurence; Budzynska, Barbara; Wolfender, Jean-Luc; Crawford, Alexander; Skalicka-Wozniak, Krystyna

doi:10.1016/j.phymed.2018.10.030

High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L (Apiaceae)

Koziol E., ŞENOL DENİZ F. S., ERDOĞAN ORHAN İ., Marcourt L., Budzynska B., Wolfender J., ...Daha Fazla

PHYTOMEDICINE, cilt.54, ss.259-264, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 54
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.phymed.2018.10.030
Dergi Adı: PHYTOMEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.259-264
Anahtar Kelimeler: Neurodegenerative disorders, Epilepsy, Zebrafish, Coumarins, Counter-current chromatography, Natural products, ANTICONVULSANT ACTIVITY, ZEBRAFISH, COUMARINS, CONSTITUENTS, FRUITS, CHOLINESTERASE, IMPERATORIN, INHIBITORS, DRUGS
Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Background: Medicinal plants are a proven source of drug-like small molecules with activity towards targets relevant for diseases of the central nervous system (CNS). Plant species of the Apiaceae family have to date yielded a number of neuroactive metabolites, such as coumarin derivatives with acetylcholinesterase inhibitory activity or anti-seizure activity.