Hemostatic parameters in Behçet's disease: A reappraisal

KOŞAR A., Öztürk M., HAZNEDAROĞLU İ. C., Karaaslan Y.

Rheumatology International, cilt.22, sa.1, ss.9-15, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1007/s00296-001-0169-4
  • Dergi Adı: Rheumatology International
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9-15
  • Anahtar Kelimeler: Behcet's disease, thrombosis, vasculitis, coagulation, fibrinolysis, hemostasis, PROTEIN-C RESISTANCE, VON-WILLEBRAND-FACTOR, ANTIENDOTHELIAL CELL ANTIBODIES, ANTICARDIOLIPIN ANTIBODIES, VENOUS THROMBOSIS, ENDOTHELIAL-CELLS, ANTITHROMBIN-III, PLASMA-LEVELS, RISK-FACTORS, E-SELECTIN
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Behçet's disease (BD) is a relapsing vasculitis in which orogenital ulceration is a prominent feature. The disease presents a tendency to thrombosis. The prevalence of venous or arterial thrombosis in BD reaches 40% in some series. Molecular markers of imbalance have been extensively studied in BD. The aim of this paper is to review current data on essential hemostatic parameters. The precise pathogenetic mechanism(s) underlying the prothrombotic state of BD is unknown. Thrombophilic factors could contribute to thrombosis in BD. Vasculitic endothelial injury may trigger or enhance the pathological hemostatic process.