Plerixafor use in patients with previous mobilization failure: A multicenter experience
Transfusion and Apheresis Science, cilt.47, sa.1, ss.77-80, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 1
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.transci.2012.05.004
- Dergi Adı: Transfusion and Apheresis Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.77-80
- Anahtar Kelimeler: Chemotherapy, Mobilization failure, Plerixafor, Stem cell mobilization
- Lokman Hekim Üniversitesi Adresli: Evet
Özet
Plerixafor in conjunction with G-CSF (G-P) is an effective strategy for hematopoietic stem cell mobilization in patients with previously failed mobilization attempt. Here we report our results with G-P among patients with at least one mobilization failure with G-CSF alone (G) or G-CSF plus chemotherapy (G-C). The study included 20 consecutive patients with lymphoma and myeloma from five centers. In 14 (70%) patients, a minimum of 2×10 6/kg CD34+ stem cells were collected and 16 out of 20 patients (80%) were able to proceed to ASCT. Our study indicates that plerixafor can safely rescue patients with a history of mobilization failure. © 2012 Elsevier Ltd.