The association between serum asymmetric dimethyl arginine levels and a history of gestational diabetes among healthy women

Gumus I. I., Kargili A., Kaygusuz I., Derbent A., Karakurt F., KASAPOĞLU B., ...Daha Fazla

BLOOD COAGULATION & FIBRINOLYSIS, cilt.23, sa.5, ss.391-395, 2012 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1097/mbc.0b013e3283468acc
  • Dergi Adı: BLOOD COAGULATION & FIBRINOLYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.391-395
  • Anahtar Kelimeler: asymmetric dimethyl arginine, deterioration of glucose metabolism, history of gestational diabetes, ENDOTHELIUM-DEPENDENT VASODILATION, OXIDE SYNTHASE PATHWAY, INSULIN-RESISTANCE, GLUCOSE-TOLERANCE, ENDOGENOUS INHIBITOR, DYSFUNCTION, PLASMA, RISK, HYPERTENSION, INFLAMMATION
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

In recent years, asymmetric dimethyl arginine (ADMA) has emerged as an early marker and/or mediator of endothelial dysfunction and it has been proved to be a novel, independent risk factor of cardiovascular and metabolic diseases. Our aim in this study was to compare the ADMA concentrations among patients with a history of gestational diabetes mellitus (GDM) with controls. Thirty women with a history of GDM and 40 age-matched and BMI-matched healthy controls were enrolled in this study. ADMA concentrations, fasting blood glucose levels, 75-g oral glucose tolerance test (OGTT) second hour plasma glucose levels, and insulin levels were compared between two groups. The fasting blood glucose levels were also significantly higher in patients with GDM history. Although second hour values of 75-g OGTT were higher in patients with GDM history, the difference between groups was not statistically significant. However, the insulin and homeostatic model assessment insulin resistance levels were statistically significantly higher in patients with a history of GDM. The concentrations of ADMA were found to be statistically higher in patients with a history of GDM (0.45 +/- 0.11 vs. 0.31 +/- 0.13 mu mol/l, respectively; P=0.01). This study shows that women who had a history of GDM are under risk for cardiovascular diseases, although they seem to be healthy and have normal blood biochemical levels, because of elevated serum ADMA levels. Clinicians should be aware of this increased cardiovascular disease risk among patients with a history of GDM. Blood Coagul Fibrinolysis 23:391-395 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.