Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin
Journal of Ethnopharmacology, cilt.107, sa.2, ss.169-174, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 107 Sayı: 2
- Basım Tarihi: 2006
- Doi Numarası: 10.1016/j.jep.2006.02.021
- Dergi Adı: Journal of Ethnopharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.169-174
- Anahtar Kelimeler: anti-inflammatory activity, antinociceptive activity, 12-O-tetradecanoyl-13-acetate (TPA), Maclura pomifera, scandenone, auriculasin, prenylated isoflavone, OSAGE ORANGE, AGGLUTININ, JACALIN
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
The aqueous, ethanolic and chloroform extracts and two prenylated isoflavones: scandenone (I) and auriculasin (II), isolated from the fruits of Maclura pomifera (Rafin.) Schneider, were investigated for their in vivo anti-inflammatory and antinociceptive activity. For the anti-inflammatory activity, both carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Scandenone, the chloroform and the ethanolic extracts were shown to possess antinociceptive activity and anti-inflammatory activity on carrageenan-induced hind paw edema model at 100 mg/kg dose. The same compound and the extract were also found to be highly active in (TPA)-induced mouse ear edema model whereas auriculasin and the H2O extract showed to be inactive in all of the assays. © 2006 Elsevier Ireland Ltd. All rights reserved.