Older age and capacity of colony forming unit in autologous peripheral derived hematopoietic cells
Transfusion and Apheresis Science, cilt.47, sa.1, ss.113-116, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 1
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.transci.2012.05.011
- Dergi Adı: Transfusion and Apheresis Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.113-116
- Lokman Hekim Üniversitesi Adresli: Evet
Özet
Background: Aging decreases bone marrow cellularity and alters the frequencies of stem cells. Aged hematopoietic stem cells can differ from their younger counterparts in functional capacity. Study design and methods: We aimed to evaluate the relation between the age and the ability of colony forming capacity of peripheral blood-derived hematopoietic cell products collected for autologous stem cell transplantation (AHSCT). Results: Elderly patients could be mobilized with lower total collected CD34+ cells. Colony forming capacity did not differ between young and old patients. Conclusion: This results can be translated into clinic as higher numbers of AHSCT candidates over age 60. © 2012 Elsevier Ltd.