Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
PHARMACEUTICAL BIOLOGY, cilt.49, sa.4, ss.396-402, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 4
- Basım Tarihi: 2011
- Doi Numarası: 10.3109/13880209.2010.519390
- Dergi Adı: PHARMACEUTICAL BIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.396-402
- Anahtar Kelimeler: Alkaloids, antimicrobial activity, antiviral activity, flavonoids, herpes simplex, parainfluenza, phenolic acids, HERPES-SIMPLEX VIRUSES, MEDICINAL-PLANTS, IN-VITRO, EXTRACTS, SILYMARIN, TYPE-1, ANTIBACTERIAL, ISOQUINOLINE, ANTIFUNGAL, HEPATITIS
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
Materials and methods: Antiviral activity of the compounds was tested against DNA virus herpes simplex type 1 and RNA virus parainfluenza (type-3). Cytotoxicity of the compounds was determined using Madin-Darby bovine kidney and Vero cell lines, and their cytopathogenic effects were expressed as maximum non-toxic concentration. Antibacterial activity was assayed against following bacteria and their isolated strains: Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis, although they were screened by microdilution method against two fungi: Candida albicans and Candida parapsilosis.