Association between blood urea nitrogen/albumin ratio and prognosis in non-small cell lung cancer

Kos M., Hocazade C., Kos F. T., Uncu D., Karakas E., Dogan M., ...Daha Fazla

Acta Medica Mediterranea, cilt.31, sa.2, ss.219-223, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 2
  • Basım Tarihi: 2015
  • Dergi Adı: Acta Medica Mediterranea
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.219-223
  • Anahtar Kelimeler: Blood Urea Nitrogen, Albumin, Ratio, Prognosis, Non-small Cell Lung Cancer, RENAL-FUNCTION, CHEMOTHERAPY, CARBOPLATIN, IMPACT
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Introduction: Prognostic value of easily available and reproducible laboratory parameters is investigated for non-small cell lung cancer (NSCLC) of which mortality is still high. We aimed to determine the prognostic value of blood urea nitrogen/albumin (BUN/ albumin) ratio. Methods: Clinicopathological characteristics with treatment modalities and laboratory values of NSCLC patients at our center evaluated retrospectively. A total of 142 patients were included to the study. Results: Median age was 57 (range 26-83). Receiver operating characteristic (ROC) curves for overall survival prediction were plotted to verify the optimum cut-off point for BUN/albumin ratio. The recommended cut-off values for BUN/albumin ratio was 0.80 with a sensitivity of 60.0% and a specificity of 60.0%. While median overall survival was 26.0 (95% CI: 14.2-37.7) months in the group with low BUN/albumin ratio (<0.80), it was calculated as 10.0 (95% CI: 5.2-14.8) months in the group with high BUN/albumin ratio (≥0.80). The difference between groups was statistically significant (p=0.005). Conclusion: BUN/albumin ratio seems to be a significant prognostic index in NSCLC. It is not only simple but also inexpensive and reproducible. However, it needs further prospective trials with large number of patients.