Synthesis and different biological activities of novel benzoxazoles
Acta Biologica Hungarica, cilt.64, sa.2, ss.249-261, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 64 Sayı: 2
- Basım Tarihi: 2013
- Doi Numarası: 10.1556/abiol.64.2013.2.10
- Dergi Adı: Acta Biologica Hungarica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.249-261
- Anahtar Kelimeler: Benzoxazoles, antibacterial activity, antifungal activity, enzyme inhibition, synthesis, TYROSINASE INHIBITORS, ANTICANCER, DERIVATIVES, ANALOGS, ACETYLCHOLINESTERASE, BENZIMIDAZOLES
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
A series of 2-[4-(4-substitutedbenzamido/phenylacetamido/butanamido)phenyl] -5-ethylsulphonyl-benzoxazole derivatives were synthesized and biologically evaluated as possible antimicrobial agents and inhibitors of tyrosinase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). The results demonstrated that the synthesized compounds exhibited a broad spectrum of activity with minimum inhibitory concentration (MIC) values of 128-16 μg/ml against some Gram-positive, Gram-negative bacteria as well as Candida albicans and C. krusei. The compound 10 displayed higher activity in this series against methicilline resistant Staphylococcus aureus (MRSA) with a MIC value of 16 μg/ml than the compared control drugs ampicillin and ceftriaxone. Compound 14 showed moderate tyrosinase inhibition, however, none of the compounds showed effect as inhibitor of AChE and BChE. © 2013 Akadémiai Kiadó, Budapest.