Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site

Ben Hadda, Taibi; Talhi, Oualid; Silva, Artur; ŞENOL DENİZ, FATMA; ERDOĞAN ORHAN, İLKAY; Rauf, Abdur; Mabkhot, Yahia; Bachari, Khaldoun; Warad, Ismail; Farghaly, Thoraya; Althagafi, Ismail; Mubarak, Mohammad

doi:10.2174/1389557517666170713114039

Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site

Ben Hadda T., Talhi O., Silva A. S. M., ŞENOL DENİZ F. S., ERDOĞAN ORHAN İ., Rauf A., ...Daha Fazla

MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.18, sa.8, ss.711-716, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Derleme
Cilt numarası: 18 Sayı: 8
Basım Tarihi: 2018
Doi Numarası: 10.2174/1389557517666170713114039
Dergi Adı: MINI-REVIEWS IN MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.711-716
Anahtar Kelimeler: Alzheimer's disease (AD), cholinesterases, crystalline structure, Petra/Osiris/Molinspiration (POM) analyses, spiro heterocycles, pharmacophore, BIOACTIVITY, ANTIBACTERIAL
Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Background: Cholinesterase family consists of two sister enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which hydrolyze acetylcholine. Since deficit of acetylcholine has been evidenced in patients of Alzheimer's disease (AD), cholinesterase inhibitors are currently the most prescribed drugs for the treatment of AD.