Evaluation of enzyme inhibitory effects and phytochemical analysis by LC-Q-ToF-MS of some Polygonum L. species growing in Türkiye

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Büyükyıldırım T., Şenol Deniz F. S., Tugay O., Aysal A. İ., Erdoğan Orhan .

TARIM BILIMLERI DERGISI, cilt.31, sa.3, ss.835-845, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 3
  • Basım Tarihi: 2025
  • Doi Numarası: 10.15832/ankutbd.1595066
  • Dergi Adı: TARIM BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Food Science & Technology Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.835-845
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Polygonum species have strong biological activity due to their important

bioactive components. Polygonum species have been studied for enzyme

inhibition activity, wound healing, anti-inflammatory, antibacterial,

antiviral, antioxidant effects, immunomodulatory activity, anti-aging

potential, estrogenic activity and are used abroad as a source of

resveratrol. For this purpose, biological activity studies, and

phytochemical analysis were carried out in P. aviculare L., P. cognatum

Meissn., P. patulum Bieb. subsp. patulum, and P. setosum Jacq. subsp.

setosum growing in Turkish flora. Polygonum ethanol extracts were tested

for their cholinesterase, elastase, collagenase, and tyrosinase enzyme inhibitory activities with spectrophotometry. P. aviculare root extract had

the highest acetylcholinesterase inhibitory activity (IC50= 55.94 ± 2.63

µg/mL), while the best butrylcholinesterase inhibitory activity was

observed for P. aviculare (IC50= 17.02 ± 3.42 µg/mL) and P. patulum

(IC50= 18.36 ± 0.15). µg/mL) root extracts. All Polygonum root extracts

showed moderate inhibitory activity against tyrosinase. In this study

indicated that P. aviculare root (IC50= 169.33 ± 3.58 µg/mL) had the

highest anti-elastase activity. P. cognatum roots (IC50= 200.30 ± 2.26

µg/mL) have potent inhibition against collagenase. LC-Q-ToF-MS

analysis in Polygonum extracts indicated that resveratrol was not present

in the extracts.