Analysis of menstrual, reproductive, and life-style factors for breast cancer risk in turkish women: A case-control study

Oran B., ÇELİK İ., ERMAN M., Baltali E., ZENGİN N., DEMİRKAZIK F., ...Daha Fazla

Medical Oncology, cilt.21, sa.1, ss.31-39, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1385/mo:21:1:31
  • Dergi Adı: Medical Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.31-39
  • Anahtar Kelimeler: breast cancer, case-control study, risk factors, COLLABORATIVE REANALYSIS, LACTATION HISTORY, INDUCED-ABORTION, CHINESE-WOMEN, MEXICAN WOMEN, BODY SIZE, AGE, ETIOLOGY, WEIGHT, PARITY
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The aim of this study was to investigate the association between menstrual, reproductive, and life-style factors and breast cancer in Turkish women. In a hospital-based case-control study in Ankara, 622 patients with histologically confirmed breast cancer were compared with 622 age-matched controls, admitted to the same hospital for acute and non-neoplastic diseases. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) related to risk factors. Overall, menopausal status and age at menopause were found to be significantly associated with breast cancer. Having a full-term pregnancy and early age at first birth were associated with decreased breast cancer risk (OR = 0.45, 95% CI = 0.30-0.66; OR = 0.34, 95% CI = 0.22-0.53, respectively). Postmenopausal women with lactation longer than 48 mo had reduced risk of breast cancer (OR = 0.36, 95% CI = 0.14-0.93). In conclusion, decreased parity, late age at first birth, early menopause, and shorter duration of lactation were the most important determinants of breast cancer risk in Turkish women.