Effects of maternally exposed food coloring additives on laryngeal histology in rats

Başak K., Doguç D. K., Aylak F., Karadayi N., Gültekin F.

Journal of Environmental Pathology, Toxicology and Oncology, cilt.33, sa.2, ss.123-130, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1615/jenvironpatholtoxicoloncol.2014008723
  • Dergi Adı: Journal of Environmental Pathology, Toxicology and Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.123-130
  • Anahtar Kelimeler: coloring food additives, genotoxicity, larynx histology, maternal exposure, SQUAMOUS-CELL CARCINOMA, CYCLOOXYGENASE-2 EXPRESSION, MESSENGER-RNA, NASAL POLYPS, LIFE-SPAN, VILLIN, ASPARTAME, COX-2, CARCINOGENICITY, DISRUPTION
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Experimental reports showed carcinogenic effects of artificial food colors and additives (AFCAs) on many organs, including the head and neck region. We aimed to investigate the effect of AFCAs on laryngeal histomorphology and immunohistochemical expression in maternally exposed rats. "No observable adverse effect levels" of commonly used AFCAs as a mixture were given to female rats before and during gestation. Histopathological and immunohistochemical findings were evaluated in their offspring. Significant decreasing in goblet cell count and cilia loss were observed with AFCAs in maternally exposed rats (p < 0.05). Immunohistochemically, the Ki67 index was significantly increased and villin expression was significantly reduced in laryngeal epithelium in the study group (p < 0.05), whereas expression of cyclooxygenase type 2, Muc-2, Muc-5AC, p53, and epidermal growth factor receptors did not differ between the groups. This study demonstrated that maternal exposure of AFCAs plays a role in the mucosal defense system and possibly in carcinogenesis. © 2014 by Begell House, Inc.