Simultaneous determination of methylene blue, hexamethylene tetramine and resorcinol in pharmaceutical formulations by first-derivative UV spectrophotometry

ONUR F., ACAR N.

International Journal of Pharmaceutics, cilt.78, sa.1-3, ss.89-91, 1992 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 1-3
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1016/0378-5173(92)90359-a
  • Dergi Adı: International Journal of Pharmaceutics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.89-91
  • Anahtar Kelimeler: SIMULTANEOUS DETERMINATION, 1ST DERIVATIVE SPECTROPHOTOMETRY, METHYLENE BLUE, HEXAMETHYLENE TETRAMINE, RESORCINOL, PHARMACEUTICAL FORMULATION
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

In this paper, rapid and precise first-derivative UV spectrophotometric assay procedures are described for the simultaneous determination of methylene blue, hexamethylene tetramine and resorcinol in their binary mixtures. The methods have been applied successfully to a dragee containing methylene blue-hexamethylene tetramine and a mouth-wash formulation containing methylene blue-resorcinol combinations. The relative standard deviation was found to be 0.71% for methylene blue at 273.0 nm and 0.70% for hexamethylene tetramine at 221.3 nm in the first combination and 0.21% for methylene blue at 300.0 nm and 0.54% for resorcinol at 260.4 nm in the second combination. © 1992.