Synthesis and potent antimicrobial activity of some novel 4-(5,6-dichloro-7H-benzimidazol-2-yl)-N-substituted benzamides
Archiv der Pharmazie, cilt.337, sa.10, ss.556-562, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 337 Sayı: 10
- Basım Tarihi: 2004
- Doi Numarası: 10.1002/ardp.200400884
- Dergi Adı: Archiv der Pharmazie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.556-562
- Anahtar Kelimeler: H-benzimidazole, benzamide, antifungal and antibacterial activity, Turkey methicillin-resistant staphylococcus aureus, methicillin-resistant staphylococcus, epidermidis, BENZIMIDAZOLES, ANTIBACTERIAL
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
A series of 4-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), methicillin-resistant S. epidermis (MRSE), Enterococcus faecalis, Escherichia coli and Candida albicans. Certain compounds inhibit bacterial growth with low MIC values (μg/mL). Among them, compounds 10 and 11 exhibited the greatest anti-bacterial activity with MIC values of 3.12 μg/mL against S. aureus, MRSA and MRSE.