The lethality, histological, haematological and biochemical alterations in mice envenomated with Aegaeobuthus nigrocinctus venom

Bakir F., Ozkan O., ALÇIĞIR M. E., YAĞMUR E. A.

Toxicon, cilt.200, ss.118-126, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 200
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.toxicon.2021.07.010
  • Dergi Adı: Toxicon
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, Environment Index, MEDLINE, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.118-126
  • Anahtar Kelimeler: Aegaeobuthus nigrocinctus Venom, Lethality, Biochemical, Haematological, Histopathology, SCORPION-VENOM, LABORATORY CHARACTERISTICS, TITYUS-SERRULATUS, MESOBUTHUS, MANIFESTATIONS, MECHANISMS, ANTIVENOM, CAPACITY, CHILDREN, PALLARY
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

© 2021 Elsevier LtdThere is currently no data regarding the toxicity or the in vivo effects of the venom the Aegaeobuthus nigrocinctus species, since it has not been studied thus far according to the best of our knowledge. In the present study, and for the first time, the median lethal dose, the in vivo toxic effects, the histological changes in some of the vital organs were all determined as well as an assessment was made of the histological, biochemical and haematological changes which were caused by the venom injected in mice. The median lethal dose (LD50) of the scorpion venom for mice was found to be 0.38 mg/kg in terms of body weight. The results of the study show that the A. nigrocintus is a potentially lethal scorpion. The evidence related to the venom indicated that it could cause tissue injury in some vital organs. In conclusion, this scorpion venom could cause significant medical complications, and may lead to death, regarding at-risk patients. Therefore, health professionals should be aware of the various scorpion species in their regions and should follow current medical approaches concerning scorpion envenomation.