Plasma thrombospondin in immune thrombocytopenic purpura


ÖZCEBE O. İ., Karakuş S., HAZNEDAROĞLU İ. C., GÖKER H., KOŞAR A., Koçoǧlu H., ...Daha Fazla

Journal of International Medical Research, cilt.30, sa.1, ss.52-55, 2002 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1177/147323000203000108
  • Dergi Adı: Journal of International Medical Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.52-55
  • Anahtar Kelimeler: Immune thrombocytopenic purpura, Plasma thrombospondin concentration, Platelet activation, Thrombospondin
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Patients with immune thrombocytopenic purpura (ITP) rarely suffer life-threatening haemorrhages despite significant thrombocytopenia, probably because large numbers of hyperfunctioning platelets are present. Thrombospondin is a platelet α-granule protein and its plasma level may reflect platelet activation. We assessed circulating thrombospondin levels in 12 newly diagnosed ITP patients (one man; 11 women, aged 36 ± 16 years) before they were treated for ITP. Twelve healthy people (four men; eight women, aged 31 ± 11 years) acted as controls. Plasma thrombospondin concentrations were measured using enzyme-linked immunoassays. Thrombospondin concentrations tended to be higher, despite thrombocytopenia, in ITP patients (158.8 ± 28.2 ng/ml) compared with controls (120.7 ± 18.2 ng/ml). The difference was not statistically significant, but the relatively high circulating thrombospondin concentrations we observed suggest that residual platelets could be activated in ITP, thus indicating a more benign clinical course compared with aplastic thrombocytopenia.