Effect of Concurrent Lidocaine, Remifentanil and Methylprednisolone Use on the Clinical Effect of Sugammadex under General Anaesthesia in Rats

KANDEMİR T., KANDEMİR E., AŞKIN T., MUSLU S., OĞUZ G., ÜNVER S.

Turkish Journal of Anaesthesiology and Reanimation, vol.47, 2019 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47
  • Publication Date: 2019
  • Doi Number: 10.5152/tjar.2019.67760
  • Journal Name: Turkish Journal of Anaesthesiology and Reanimation
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Keywords: Lidocaine, methylprednisolone, neuromuscular blockade, remifentanil, sugammadex, NEUROMUSCULAR BLOCKADE, REVERSAL
  • Lokman Hekim University Affiliated: No

Abstract

Objective: In an in vitro study, lidocaine, remifentanil and methylprednisolone produced inclusion complexes with sugammadex, which lead to a decrease in free and active concentrations of sugammadex. When used concurrently with these drugs, it is likely that the time for sugammadex to reverse a neuromuscular blockade is going to be prolonged due to a synergistic pharmacokinetic or pharmacodynamic interaction. The aim of the present study was to investigate whether concurrent use of sugammadex with remifentanil, lidocaine and methylprednisolone led to a decrease in the neuromuscular blockade reversal effect of sugammadex produced with neuromuscular blockade agent (NMBA) rocuronium.