Effect of Concurrent Lidocaine, Remifentanil and Methylprednisolone Use on the Clinical Effect of Sugammadex under General Anaesthesia in Rats


KANDEMİR T. , KANDEMİR E., AŞKIN T., MUSLU S., OĞUZ G., ÜNVER S.

Turkish Journal of Anaesthesiology and Reanimation, vol.47, 2019 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47
  • Publication Date: 2019
  • Doi Number: 10.5152/tjar.2019.67760
  • Title of Journal : Turkish Journal of Anaesthesiology and Reanimation
  • Keywords: Lidocaine, methylprednisolone, neuromuscular blockade, remifentanil, sugammadex, NEUROMUSCULAR BLOCKADE, REVERSAL

Abstract

Objective: In an in vitro study, lidocaine, remifentanil and methylprednisolone produced inclusion complexes with sugammadex, which lead to a decrease in free and active concentrations of sugammadex. When used concurrently with these drugs, it is likely that the time for sugammadex to reverse a neuromuscular blockade is going to be prolonged due to a synergistic pharmacokinetic or pharmacodynamic interaction. The aim of the present study was to investigate whether concurrent use of sugammadex with remifentanil, lidocaine and methylprednisolone led to a decrease in the neuromuscular blockade reversal effect of sugammadex produced with neuromuscular blockade agent (NMBA) rocuronium.