Effect of Concurrent Lidocaine, Remifentanil and Methylprednisolone Use on the Clinical Effect of Sugammadex under General Anaesthesia in Rats

KANDEMİR T., KANDEMİR E., AŞKIN T., MUSLU S., OĞUZ G., ÜNVER S.

Turkish Journal of Anaesthesiology and Reanimation, cilt.47, 2019 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/tjar.2019.67760
  • Dergi Adı: Turkish Journal of Anaesthesiology and Reanimation
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Anahtar Kelimeler: Lidocaine, methylprednisolone, neuromuscular blockade, remifentanil, sugammadex, NEUROMUSCULAR BLOCKADE, REVERSAL
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Objective: In an in vitro study, lidocaine, remifentanil and methylprednisolone produced inclusion complexes with sugammadex, which lead to a decrease in free and active concentrations of sugammadex. When used concurrently with these drugs, it is likely that the time for sugammadex to reverse a neuromuscular blockade is going to be prolonged due to a synergistic pharmacokinetic or pharmacodynamic interaction. The aim of the present study was to investigate whether concurrent use of sugammadex with remifentanil, lidocaine and methylprednisolone led to a decrease in the neuromuscular blockade reversal effect of sugammadex produced with neuromuscular blockade agent (NMBA) rocuronium.