Effect of Concurrent Lidocaine, Remifentanil and Methylprednisolone Use on the Clinical Effect of Sugammadex under General Anaesthesia in Rats
Turkish Journal of Anaesthesiology and Reanimation, cilt.47, 2019 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47
- Basım Tarihi: 2019
- Doi Numarası: 10.5152/tjar.2019.67760
- Dergi Adı: Turkish Journal of Anaesthesiology and Reanimation
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Anahtar Kelimeler: Lidocaine, methylprednisolone, neuromuscular blockade, remifentanil, sugammadex, NEUROMUSCULAR BLOCKADE, REVERSAL
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
Objective: In an in vitro study, lidocaine, remifentanil and methylprednisolone produced inclusion complexes with sugammadex, which lead to a decrease in free and active concentrations of sugammadex. When used concurrently with these drugs, it is likely that the time for sugammadex to reverse a neuromuscular blockade is going to be prolonged due to a synergistic pharmacokinetic or pharmacodynamic interaction. The aim of the present study was to investigate whether concurrent use of sugammadex with remifentanil, lidocaine and methylprednisolone led to a decrease in the neuromuscular blockade reversal effect of sugammadex produced with neuromuscular blockade agent (NMBA) rocuronium.