Synthesis and antimicrobial activity of some benzazole derivatives

---

Atıf İçin Kopyala

KARALI N. L., Cesur N., Gürsoy A., Ateş Ö., ÖZDEN M. S., Ötük G., ...Daha Fazla

Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, cilt.43, sa.1, ss.212-216, 2004 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 43 Sayı: 1
• Basım Tarihi: 2004
• Dergi Adı: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.212-216
• Lokman Hekim Üniversitesi Adresli: Hayır

Özet

A series of 2-(1H-benzimidazol/1,3-benzoxazol/1,3-benzothiazol-2- ylmercapto)-N-(1,5-dimethyl-2-phenyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl) acylamines 5a-h and 2-(1H-benzimidazol-2-ylmercapto)-N-(5-substituted-2-oxo-1,2- dihydro-3H-indol-3-ylidene)acetohydrazides 8a-e have been synthesized. Their structures are determined by the elemental analyses and spectral data (IR, 1H-NMR, EIMS). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis ATCC 14153 and Candida albicans ATCC 10231. 8a, 8c and 8e demonstrating activity against Staphylococcus epidermidis ATCC 12228 in the primary screen are re-tested at lower concentrations to determine the actual minimum inhibitory concentration (MIC).