Aim: The aim of the present study was to investigate the clinical, histopathological and immunohistochemical characteristics of Hodgkin's lymphoma (HL) in the city of Sanliurfa in Turkey. Methods: Thirty-two cases that had been diagnosed as HL and of which complete clinical and histopathological information could be fully accessed at our hospital clinics between 2002 and 2013 were included in the present study. The clinical, histopathological and immunohistochemical findings were retrospectively examined. Results: The male/female ratio was 2.2. The average age of the subjects was 29.9±24.4. The distribution of the ages of these cases, in terms of decades, was 31.3% in the first decade, 9.4% in the second decade, 21.9% in the third decade, 6.3% in the fourth decade and 28.1% in the fifth or a subsequent decade. The most frequent localization site was cervical region (56.3%). The most frequent symptom was pain-free lymphadenopathy (81.3%). On a macroscopic level, 68.8% of them were found to have lymphatic nodes that were larger than normal. With respect to the histological sub-types, nearly every case was classical HL, 40.6% of the cases were identified as having the mixed cellular type, 40.6% had the nodular sclerosing type and 9.4% had the lymphocyte rich type. Hodgkin/Reed-Sternberg cells were CD15-positive in 91.6% of the cases, CD30-positive in 100% and CD20-positive in 20%. Conclusion: Our epidemiological data are generally compatible with data from both underdeveloped and developing countries. The results of immunohistochemical staining that we have obtained in this study are in line with the literature data.