Amendatory effect of flavonoids in alzheimer's disease against mito-chondrial dysfunction

Gulcan H. O., ERDOĞAN ORHAN İ.

Current Drug Targets, cilt.22, sa.14, ss.1618-1628, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 22 Sayı: 14
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1389450122666210120144921
  • Dergi Adı: Current Drug Targets
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1618-1628
  • Anahtar Kelimeler: Flavonoids, Alzheimer's disease, mitochondrial dysfunction, reactive oxygen species, amyloid beta, chromene ana-logues, H2O2-INDUCED MITOCHONDRIAL DYSFUNCTION, NITRIC-OXIDE SYNTHASE, AMYLOID-BETA-PROTEIN, OXIDATIVE STRESS, REACTIVE OXYGEN, CHOLINERGIC HYPOTHESIS, ANTIBACTERIAL ACTIVITY, DIETARY FLAVONOIDS, MAJOR FLAVONOIDS, IN-VITRO
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© 2021 Bentham Science Publishers.Flavonoids are chromene analogues abundantly found in plants. It has always been of in-terest to discover natural flavonoid structures, since living things, including humans, are routinely exposed to these compounds through many dietaries. So far, numerous studies have been conduct-ed on flavonoids with diverse biological actions. The activity results obtained, particularly regard-ing the effects of flavonoids on various validated and non-validated targets of Alzheimer’s Disease (AD), make these compounds promising agents either to be directly employed in clinical trials or to be utilized as important scaffolds for flavonoid-based drug design studies. Although there are many review articles on the treatment and protective effects of flavonoids on AD, within this re-view, the effects of flavonoids on mitochondrial dysfunction developing throughout AD have been presented concomitant to their structural organization.