Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents

Turan-Zitouni G., Kaplancikli Z. A., Özdemir A., Chevallet P., Kandilci H. B., Gümüsel B.

Archiv der Pharmazie, cilt.340, sa.11, ss.586-590, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 340 Sayı: 11
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/ardp.200700134
  • Dergi Adı: Archiv der Pharmazie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.586-590
  • Anahtar Kelimeler: anti-inflammatory activity, carrageenan induced oedema, triazole, INHIBITORS, CYCLOOXYGENASE-2, INDOMETHACIN, AMIDES, ESTER, EDEMA, DRUG
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The reaction of acetic or propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the 1,2,4-triazoles by alkali cyclization. The 4-aryl/alkyl-5-(1-phenoxyethyl)-3-[N-(substituted) acetamido]thio-4H-1,2,4-triazole derivatives were synthesized by reacting the triazoles with 2-chloro-N-(substituted)acetamide. The chemical structures of the compounds were elucidated by IR, 1H-NMR, FAB+-MS spectral data and elemental analysis. In the pharmacological studies, anti-inflammatory activities of these compounds have been screened and significant activities were observed. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.