Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents


Turan-Zitouni G., Kaplancikli Z. A. , Özdemir A., Chevallet P., Kandilci H. B. , Gümüsel B.

Archiv der Pharmazie, vol.340, no.11, pp.586-590, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 340 Issue: 11
  • Publication Date: 2007
  • Doi Number: 10.1002/ardp.200700134
  • Journal Name: Archiv der Pharmazie
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.586-590
  • Keywords: anti-inflammatory activity, carrageenan induced oedema, triazole, INHIBITORS, CYCLOOXYGENASE-2, INDOMETHACIN, AMIDES, ESTER, EDEMA, DRUG

Abstract

The reaction of acetic or propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the 1,2,4-triazoles by alkali cyclization. The 4-aryl/alkyl-5-(1-phenoxyethyl)-3-[N-(substituted) acetamido]thio-4H-1,2,4-triazole derivatives were synthesized by reacting the triazoles with 2-chloro-N-(substituted)acetamide. The chemical structures of the compounds were elucidated by IR, 1H-NMR, FAB+-MS spectral data and elemental analysis. In the pharmacological studies, anti-inflammatory activities of these compounds have been screened and significant activities were observed. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.