Adenine nucleotide pattern in rat pancreatic islets exposed to nutrient secretagogues

Agascioglu E. A., Giroix M., Malaisse W. J., Sener A.

Endocrine, cilt.29, sa.2, ss.325-329, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1385/endo:29:2:325
  • Dergi Adı: Endocrine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.325-329
  • Anahtar Kelimeler: pancreatic islets, ATP and ADP content, insulin release, nutrient secretagogues, INDUCED INSULIN-RELEASE, L-GLUTAMINE, HEXOSE METABOLISM, D-GLUCOSE, L-LEUCINE, SECRETION, FUEL, STIMULATION, GLYCOLYSIS
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The effects of D-glucose, D-mannose, D-galactose, Dglyceraldehyde, pyruvate, L-lactate, 2-ketoisocaproate, L-leucine, and/or L-glutamine on the ATP and ADP content of rat isolated pancreatic islets were reevaluated in order to compare changes evoked by these nutrient secretagogues in the islet ATP content and ATP/ADP ratio to their effects upon insulin release. Although being compatible with the fuel concept for nutrient-stimulated insulin secretion, the results of this study also argue against the monolithic view that the adenine nucleotide pattern in islet cells represents the sole coupling factor between metabolic and more distal events in the process of nutrient-stimulated insulin release. © 2006 by Humana Press Inc. All rights of any nature whatsoever reserved.