Remifentanil versus fentanyl for analgesia based sedation in mechanically ventilated patients Remifentanil ve fentanilin yoǧun bakim hastalarinda analjezi bazli sedasyonda karşilaştirilmasi

AKINCI S. B., SARICAOĞLU F., Kanbak M., Güler A., AYPAR Ü.

Anestezi Dergisi, cilt.13, sa.3, ss.182-188, 2005 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 3
  • Basım Tarihi: 2005
  • Dergi Adı: Anestezi Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.182-188
  • Anahtar Kelimeler: Fentanyl, ICU patients, Mechanical ventilation, Remifentanil, Sedation
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Analgesia based sedation techniques are becoming more established in the ICU setting. The aim of this study was to compare remifentanil and fentanyl infusions for postoperative analgesia in ICU patients. After receiving ethic committee approval, a prospective randomised, double-blind study was performed. 44 ICU patients received either remifentanil 0.1 μg kg-1 min-1 or fentanyl 0.025 μg kg-1 min-1 infusions diluted to the same volume. Analgesic infusion was titrated to predefined levels of analgesia (Behavioural pain scale (BPS) score of 3). Propofol was added if sedation was unsatisfactory (Riker Sedation agitation Scale>4) after BPS score 3 had been achieved. There were no differences in groups regarding demographics, tracheal extubation times and pain scores of the patients. The incidences of nausea, vomiting, apnea, desaturation, reintubation within 24 hours, constipation were also similar between the two groups. We conclude that remifentanil infusion provides clinically comparable analgesia to fentanyl infusion in mechanically ventilated patients. The two drugs are suitable for analgesia based sedation in ICU patients.