Oxidative and Inflammatory Parameters in Children and Adolescents With ADHD

Koç S., Güler E. M., DERİN S., GÜLTEKİN F., Aktaş S.

Journal of Attention Disorders, cilt.27, sa.8, ss.880-886, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 8
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1177/10870547231159907
  • Dergi Adı: Journal of Attention Disorders
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, CINAHL, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.880-886
  • Anahtar Kelimeler: antioxidant, attention deficit hyperactivity disorder, IL-6, inflammation, oxidative stress
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Objective: This study aims that oxidative stress and inflammation status in children and adolescents with attention deficit hyperactivity disorder (ADHD) compared to their healthy peers. Method: Thirty ADHD and healthy controls were included in this study. ADHD diagnosis according to the DSM-V and Conners’ teacher and parent rating scale by a structured psychiatric interview. Total oxidant status (TOS), total antioxidant status (TAS), and total and native thiol levels were determined using photometric methods. Presepsin, Interleukin (IL) 1-ß, IL-6, and Tumor Necrosis Factor-alpha (TNF-α) levels were measured with commercial ELISA kits. Results: We showed that TOS and oxidative stress index were significantly higher in the ADHD group, and TAS was lower than in the control group (p<.001). Similarly, IL1-ß, IL-6, and TNF-α levels were statistically higher in the ADHD group. Backward LR regression analysis reveals that TOS and IL-6 predicted ADHD. Conclusion: TOS and IL-6 levels may play a role in the pathogenesis of ADHD.