Assesment of carvacrol effects on acetaminophen related hepatotoxicity and and its comparison with N-acetyl cystein Asetami̇nofen'i̇n neden olduǧu hepatotoksi̇si̇tede karvakrol'ün etki̇si̇ni̇n deǧerlendi̇ri̇ lmesi̇ ve N-aseti̇l si̇stei̇n i̇le karşilaş tirilmasi


Turgut H. C., Erden I. A., AKINCI S. B., SARICAOĞLU F., Önder S., Kilinç K., ...More

Anestezi Dergisi, vol.22, no.1, pp.13-17, 2014 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2014
  • Journal Name: Anestezi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.13-17
  • Keywords: Acetaminophen, Carvacrol, Hepatotoxicity, N-acetyl cysteine
  • Lokman Hekim University Affiliated: Yes

Abstract

Objective: Acetaminophen is an analgesics agent with little side effects in range of therapeutic doses while hepatotoxicity is a common consequence of acetaminophen overdose. There has been beneficial effects of carvarcol on hepatic regeneration and ischemi-reperfusion injury. In this study we have aimed to examine the effects of carvacrol on acetaminophen induced hepatotoxiciy and compare it with N-acetyl cysteine (NAS). Material-Methods: Thirty six Wistar Albino rats have been used for the study (6 groups). In group 1 animals recieved carvacrol of 73 mg kg-1 intraperitoneally after receiving 1gr kg-1 APAP orally. Animals in control group received saline of 1 ml kg-1 orally. In group 3 animals recieved carvacrol of 73 mg kg -1 intraperitoneally. In group 4 animals recieved 1gr kg-1 of APAP orally followed by 1.2 gr kg-1 of NAC intraperitoneally. In group 5 animals received APAP of 1 gr kg-1 orally. In group 6 animals received NAC of 1.2 gr kg-1 intraperitoneally. Alanine amino transferase (ALT), aspartat amino transferase (AST) and alkaline phospatase (ALP) levels were measured after 24 hours, and histopathological examination was made. Results: Inflammation in APAP treated group, N-acetyl cysteine treated group and APAP+NAC group was remarkably high (p<0.05). Serum levels of ALT and AST were found to be higher in carvacrol treated group than APAP treated group and APAP+NAC treated group (p<0.05). Conclusion: Our study indicates that carvacrol can not provide sufficent protective effect, and neither carvacrol nor N-acetyl cysteine is superior to each other in protecting hepatocytes from acetaminophen induced hepatotoxicity. Carvacrol has no destructing effect on hepatic tissue according to histopathological findings, however, this result has been debatable due to the significant increase in carvacrol related aminotransferase levels.