Novel chromosomal translocations in multiple myeloma: t(13;16)(q14;q24) and t(1;15)(q10;q26)

Akalin I., KUTLAY N., İLHAN ., Tukun A.

International Journal of Laboratory Hematology, cilt.29, sa.3, ss.215-220, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1751-553x.2006.00837.x
  • Dergi Adı: International Journal of Laboratory Hematology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.215-220
  • Anahtar Kelimeler: +i(1)(q10), inv(9)(p11q13), Multiple myeloma, t(13;16), t(1;15), Translocation
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Multiple myeloma (MM) is a malignant plasma cell disorder that involves multiple genetic abnormalities. Chimeric transcription factors, created by gene fusion as a result of chromosomal translocations, have been implicated in the pathogenesis of the disease. Here, we report the conventional cytogenetic analysis of a MM patient that showed a complex set of novel chromosomal rearrangements, including t(13;16)(q14;q24) and t(1;15)(q10;q26). This is probably the result of fusion of previously known genes, and would contribute to prognostic significance of the disease. © 2007 The Authors.