© 2018, Romanian Society for Pharmaceutical Sciences. All rights reserved.Different habitats of seas and oceans made them an enormous source of biodiversity. Seven different marine species (Coral, Anemon, Tunicate) were tested in a screening platform for the identification of their potential bioactivity related to antimicrobial, cytotoxicity, tyrosinase inhibitory activity. Antimicrobial activity was carried out by broth dilution methods, used to determine the minimum inhibitory concentration (MIC). The cytotoxic activity of the samples was carried out by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The tyrosinase inhibitory potentials of selected species extracts were determined using ELISA microtiter assays. The tyrosinase inhibitory activity of these species is the most important result obtained within the experiment.