Serum uric acid level is an independent risk factor for presence of calcium in coronary arteries: An observational case-controlled study Serum ürik asit düzeyi koroner arter kalsiyum varliǧinin baǧimsiz bir belirleyicisidir: Bir gözlemsel vaka kontrollü çalişma


Atar A. I. , Çaǧlar Yilmaz Ö., AKIN K. , Selçoki Y., Er O., Eryonucu B.

Anadolu Kardiyoloji Dergisi, vol.13, no.2, pp.139-145, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.5152/akd.2013.039
  • Title of Journal : Anadolu Kardiyoloji Dergisi
  • Page Numbers: pp.139-145
  • Keywords: Uric acid, coronary artery calcium score, coronary heart disease, logistic regression analysis, ALL-CAUSE MORTALITY, CARDIOVASCULAR-DISEASE, COMPUTED-TOMOGRAPHY, HEART-DISEASE, CALCIFICATION, HYPERURICEMIA, HYPERTENSION, ASSOCIATION, PREDICTION, GLUCOSE

Abstract

Objective: A link between uric acid levels and cardiovascular diseases has been previously reported. Coronary artery calcium score (CACS) is a marker of atherosclerotic disease and a predictor of cardiovascular events. We sought to determine if serum uric acid level is an independent risk factor for the presence of calcium in coronary arteries. Methods: Four hundred and forty-two patients who were evaluated in the cardiology outpatient clinic for suspected coronary heart disease with a low-moderate risk for coronary artery disease were included in this observational case-controlled study. Serum uric acid levels were measured with colorimetric methods. CACS were performed using a 64-slice CT scanner. Patients were divided to 3 groups according to their CACS value (Group 1: CACS=0, Group 2: CACS 1-100, Group 3: CACS>100). Results: The demographical characteristics and laboratory findings of 3 groups were similar, except age, fasting glucose levels and serum uric acid levels. Serum uric acid levels were found to increase significantly with increasing CACS (p=0.001). Patients were grouped according to presence CAC (CACS=0 and CACS≥1) and in the multiple regression analysis, age (OR, 1.11, 95% CI, 1.07-1.16), smoking (OR, 3.83, 95% CI, 2.06-7.09), serum uric acid levels (OR, 1.26, 95% CI, 1.04-1.54) and average 10-year total risk of Framingham risk score (OR, 1.13, 95% CI, 1.04-1.09) appeared as independent factors predictive of presence of CAC (p<0.05). Conclusion: Serum uric acid level is an independent risk factor for presence of coronary calcium. Moreover, increasing levels of serum uric acid are associated with increasing CACS. © Telif Hakki̇ 2013 AVES Yayi̇nci̇li̇k Ltd.