Potent antifungal and antistaphylococcal 2-anilinobenzimidazoles

GÖKER A. H., Karaaslan C., YILDIZ S.

Zeitschrift fur Naturforschung - Section C Journal of Biosciences, cilt.67 C, sa.9-10, ss.486-494, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 C Sayı: 9-10
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1515/znc-2012-9-1007
  • Dergi Adı: Zeitschrift fur Naturforschung - Section C Journal of Biosciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.486-494
  • Anahtar Kelimeler: Anilinobenzimidazoles, Antifungal activity, Antistaphylococcal activity
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

A series of 21 anilinobenzimidazoles with a 2,4-difluorophenyl group were synthesized and their minimum inhibitory concentrations (MIC) determined by the tube dilution method. Most of the compounds exhibited excellent MIC values against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Among them, compound 27 having dibromo substitution at the 4- and 6-position of the benzimidazole ring showed the best antifungal activity against Candida krusei with a MIC value of 3.12 μg/mL that surpassed that of the reference drug fluconazole. © 2012 Verlag der Zeitschrift für Naturforschung, Tübingen.