Potent antifungal and antistaphylococcal 2-anilinobenzimidazoles

GÖKER A. H. , Karaaslan C., YILDIZ S.

Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol.67 C, no.9-10, pp.486-494, 2012 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 C Issue: 9-10
  • Publication Date: 2012
  • Doi Number: 10.1515/znc-2012-9-1007
  • Title of Journal : Zeitschrift fur Naturforschung - Section C Journal of Biosciences
  • Page Numbers: pp.486-494
  • Keywords: Anilinobenzimidazoles, Antifungal activity, Antistaphylococcal activity


A series of 21 anilinobenzimidazoles with a 2,4-difluorophenyl group were synthesized and their minimum inhibitory concentrations (MIC) determined by the tube dilution method. Most of the compounds exhibited excellent MIC values against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Among them, compound 27 having dibromo substitution at the 4- and 6-position of the benzimidazole ring showed the best antifungal activity against Candida krusei with a MIC value of 3.12 μg/mL that surpassed that of the reference drug fluconazole. © 2012 Verlag der Zeitschrift für Naturforschung, Tübingen.