Potent antifungal and antistaphylococcal 2-anilinobenzimidazoles

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GÖKER A. H., Karaaslan C., YILDIZ S.

Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol.67 C, no.9-10, pp.486-494, 2012 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 67 C Issue: 9-10
• Publication Date: 2012
• Doi Number: 10.1515/znc-2012-9-1007
• Journal Name: Zeitschrift fur Naturforschung - Section C Journal of Biosciences
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.486-494
• Keywords: Anilinobenzimidazoles, Antifungal activity, Antistaphylococcal activity
• Lokman Hekim University Affiliated: No

Abstract

A series of 21 anilinobenzimidazoles with a 2,4-difluorophenyl group were synthesized and their minimum inhibitory concentrations (MIC) determined by the tube dilution method. Most of the compounds exhibited excellent MIC values against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Among them, compound 27 having dibromo substitution at the 4- and 6-position of the benzimidazole ring showed the best antifungal activity against Candida krusei with a MIC value of 3.12 μg/mL that surpassed that of the reference drug fluconazole. © 2012 Verlag der Zeitschrift für Naturforschung, Tübingen.