Application of the BRAFO tiered approach for benefit-risk assessment to case studies on dietary interventions

Verhagen H., Andersen R., Antoine J., Finglas P., Hoekstra J., Kardinaal A., ...Daha Fazla

Food and Chemical Toxicology, cilt.50, sa.SUPPL4, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: SUPPL4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.fct.2011.06.068
  • Dergi Adı: Food and Chemical Toxicology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Benefit-risk assessment, BRAFO, Dietary interventions, Folic acid, SAFA, Tiered approach
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

The respective examples, described in this paper, illustrate how the BRAFO-tiered approach, on benefit-risk assessment, can be tested on a wide range of case studies. Various results were provided, ranging from a quick stop as the result of non-genuine benefit-risk questions to continuation through the tiers into deterministic/probabilistic calculations. The paper illustrates the assessment of benefits and risks associated with dietary interventions. The BRAFO tiered approach is tested with five case studies. In each instance, the benefit-risk approach is tested on the basis of existing evaluations for the individual effects done by others; no new risk or benefit evaluations were made. The following case studies were thoroughly analysed: an example of food fortification, folic acid fortification of flour, macronutrient replacement/food substitution; the isocaloric replacement of saturated fatty acids with carbohydrates; the replacement of saturated fatty acids with monounsaturated fatty acids; the replacement of sugar-sweetened beverages containing mono- and disaccharides with low calorie sweeteners and an example of addition of specific ingredients to food: chlorination of drinking water. © 2011 ILSI Europe.