C-reactive Protein–Albumin Ratio: New Marker in Mortality Risk and Disease Severity in Pulmonary Thromboembolism
Journal of Association of Physicians of India, cilt.74, sa.10, ss.36-40, 2026 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 74 Sayı: 10
- Basım Tarihi: 2026
- Doi Numarası: 10.59556/japi.74.1707
- Dergi Adı: Journal of Association of Physicians of India
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.36-40
- Anahtar Kelimeler: C-reactive protein–albumin ratio, Inflammatory markers, Mortality risk, Prognostic biomarker, Pulmonary thromboembolism
- Lokman Hekim Üniversitesi Adresli: Evet
Özet
Background: Pulmonary thromboembolism (PTE), with increasing incidence and decreasing mortality rate, is still a common cause of cardiovascular mortality today. The aim of this study was to evaluate the clinical relationship between disease severity and mortality risk and C-reactive protein (CRP)–albumin ratio (CAR) in patients admitted to the hospital with acute PTE. Materials and methods: In this single-center, retrospective study, 215 patients diagnosed with PTE between 2012 and 2022 were included. All patients were divided into four groups according to mortality risk. Results: A total of 47 patients were in the low-risk group, 91 patients were in the intermediate-low-risk group, 59 patients were in the intermediate-high-risk group, and 18 patients were in the high-risk group. There was a statistically significant difference between mortality risk groups in terms of CAR and other biochemical parameters (p < 0.001). A positive correlation between CAR and mortality risk, troponin, D-dimer, pro-brain natriuretic peptide (pro-BNP), simplified Pulmonary Embolism Severity Index (sPESI), and systolic pulmonary artery blood pressure (sPAB) parameters (rs=0.440, p < 0.001; rs=0.277, p < 0.001; rs=0.215, p=0.001; rs=0.236, p=0.001; rs=0.318, p < 0.001; rs=0.201, p=0.005, respectively), and a negative correlation with tricuspid annular plane systolic excursion (TAPSE) (rs=−0.167, p < 0.001) were found. In the receiver operating characteristic (ROC) analysis, CAR demonstrated a high discriminative ability in predicting high mortality risk, with an area under the curve (AUC) of 0.928. Conclusion: This study shows that CAR may have clinical importance in PTE patients, helping to predict prognosis and guide treatment strategies. Its simplicity and cost-effectiveness may offer advantages in practice. However, further studies are needed to validate CAR in larger populations.