Effect of hyaluronic acid on the osseointegration of dental implants

Yazan M., Kocyigit I., Atil F., Tekin U., GÖNEN Z. B., Onder M.

British Journal of Oral and Maxillofacial Surgery, vol.57, no.1, pp.53-57, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.1016/j.bjoms.2018.08.014
  • Journal Name: British Journal of Oral and Maxillofacial Surgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.53-57
  • Keywords: Bone Repairing, Dental implant, Histopathology, Hyaluronic acid, Osseointegration, Rabbit Mandible
  • Lokman Hekim University Affiliated: No


The mechanism of osseointegration is related to many factors, including the quality of the bone, the biocompatibility and surface characteristics of the implant material, the surgical technique, and functional loading. The purpose of this study was to investigate the effects of hyaluronic acid gel on the osseointegration of implants placed in defined areas of the mandible in rabbits. Hyaluronic acid is known to have an osteoinductive effect during regeneration of bony defects, and we thought that it might also have a favourable effect on osseointegration, a specialised mechanism to heal bone. Ten New Zealand rabbits aged 10 weeks and weighing 2.5–3.0 kg were used, and sites for implants that were far enough from the apices of the teeth in the mandibular molar area were chosen. Two cavities were prepared in each rabbit, one (anterior) for the control implant, and one (posterior) for the implant with hyaluronic acid gel (Medical Instinct GmbH, Bovenden). New bone and the osteoid matrix content around the dental implants were evaluated histologically and histomorphometrically two months after the operation, and no significant difference was found between the two groups.