Association of parity with osteoprotegerin levels and atherosclerosis

Eren M. A., Vural M., Yildiz S., Cece H., Camuzcuoglu H., Toy H., ...More

Archives of Gynecology and Obstetrics, vol.287, no.6, pp.1081-1086, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 287 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1007/s00404-012-2703-x
  • Journal Name: Archives of Gynecology and Obstetrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1081-1086
  • Keywords: Carotid intima-media thickness, Osteoprotegerin, Parity
  • Lokman Hekim University Affiliated: No


Purpose: Association of serum osteoprotegerin (OPG) levels and cardiovascular disorders has been shown previously. The aim of this observational study was to investigate the relationship between parity, OPG and carotid intima-media thickness (CIMT) in premenopausal women. Methods: A total of 128 women (mean age ± SD, 37.8 ± 4.7 years) were divided into three group according to parity [1-3 as group 1 (n = 41), 4-6 as group 2 (n = 55) and ≥7 as group 3 (n = 32)]. Serum OPG was measured and CIMT was evaluated. Results: Both serum OPG levels and CIMT tended to increase with advancing parity; OPG level was significantly higher in group 3 than in group 1 (p = 0.013) and CIMT was significantly higher in group 2 and group 3 than in group 1 (p < 0.001 for both). In correlation analyses, there were significant correlations between all three parameters. Conclusions: Our results revealed that there was an increased risk of cardiovascular disease in women with multiparity. Significant association of OPG with CIMT suggested that OPG might play a role in the pathogenesis of parity-induced atherosclerosis. © 2013 Springer-Verlag Berlin Heidelberg.