Association of parity with osteoprotegerin levels and atherosclerosis

Eren M. A., Vural M., Yildiz S., Cece H., Camuzcuoglu H., Toy H., ...Daha Fazla

Archives of Gynecology and Obstetrics, cilt.287, sa.6, ss.1081-1086, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 287 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00404-012-2703-x
  • Dergi Adı: Archives of Gynecology and Obstetrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1081-1086
  • Anahtar Kelimeler: Carotid intima-media thickness, Osteoprotegerin, Parity
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Purpose: Association of serum osteoprotegerin (OPG) levels and cardiovascular disorders has been shown previously. The aim of this observational study was to investigate the relationship between parity, OPG and carotid intima-media thickness (CIMT) in premenopausal women. Methods: A total of 128 women (mean age ± SD, 37.8 ± 4.7 years) were divided into three group according to parity [1-3 as group 1 (n = 41), 4-6 as group 2 (n = 55) and ≥7 as group 3 (n = 32)]. Serum OPG was measured and CIMT was evaluated. Results: Both serum OPG levels and CIMT tended to increase with advancing parity; OPG level was significantly higher in group 3 than in group 1 (p = 0.013) and CIMT was significantly higher in group 2 and group 3 than in group 1 (p < 0.001 for both). In correlation analyses, there were significant correlations between all three parameters. Conclusions: Our results revealed that there was an increased risk of cardiovascular disease in women with multiparity. Significant association of OPG with CIMT suggested that OPG might play a role in the pathogenesis of parity-induced atherosclerosis. © 2013 Springer-Verlag Berlin Heidelberg.