Akademik Veri Yönetim Sistemi
Acta Biomedica, cilt.95, sa.5, 2024 (Scopus)
Purpose: To compare pre-and post-treatment measurements in patients diagnosed with laryn-gopharyngeal reflux (LPR), and to compare patients with gastroesophageal reflux disorder (GERD) who exhibit symptoms of laryngopharyngeal reflux to those who do not, using a combined algorithm. Methods: This prospective cohort study involved 384 patients and used the following algorithm: a Reflux Symptom Index (RSI) questionnaire score of >13, videolaryngostroboscopy with an assessment of the Reflux Finding Score (RFS) >7, pH strips of mucus from the laryngopharynx, and acoustic analysis of the voice in singers with voice disorders. Patients with LPR and GERD were treated with proton pump inhibitors at a dose of 20 mg twice a day and were given lifestyle and dietary changes recommendations for one month. The patients were monitored for six months. Results: After treatment, RSI and RFS results in patients with LPR and GERD significantly improved from 19.9±6.4 & 9.1±1.7 and 18.7±5.3 & 10.10±2.4 respectively (p<0.001). In patients without the symptoms of LPR, the laryngopharyngeal medium pH ranged from min 5.5 to max 7.5, and in cases of suspected LPR and GERD, it ranged from min 5 to max 8 and min and 4.5 to max 8.5 respectively. The acoustic voice analysis scores changed after therapy, p-value<0.05. Conclusion: The lack of a gold standard and the inaccessibility of diagnostic methods make LPR diagnosis a very complex task. However, using the proposed diagnostic algorithm, the post treatment scores were improved. More studies are needed to validate the algorithm for early diagnosis of LPR. (www.actabiomedica.it).