Comparative assessment of hemodynamic and anesthetic sparing effects of esmolol and dexmedetomine during induction of anesthesia Esmolol ve Deksmedetomidin'in Anestezi İndüksiyonunda Kullaniminin Hemodinami ve Anestezik Gereksinimi Açisindan Karşilaştirilmasi


Anestezi Dergisi, vol.13, no.4, pp.247-252, 2005 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2005
  • Journal Name: Anestezi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.247-252
  • Keywords: Dexmedetomine, Endotracheal intubation, Esmolol, Laryngoscopy
  • Lokman Hekim University Affiliated: Yes


In this placebo-controlled, double-blind, prospective study, the aim was to compare the propofol requirements and the hemodynamic effects of esmolol and dexmedetomidine during laryngoscopy and endotracheal intubation. The ASA I-II group consisted of sixty one volunteer patients, whose age ranged between 18-65 and who underwent elective surgery. Patients were divided into three groups. Infusions of dexmedetomidine (1 μg kg-1h-1) were given to the first group (Group D) esmolol (250 μg kg-1 min-1) to the second group (Group E) and isotonic fluid (0.5 ml kg-1 min-1) to the third group (Group C). Infusions started 10 minutes before application of the induction agent and finished three minutes after intubation. Induction with propofol was given at the tenth minute; and evaluating the verbal response, the amount of propofol given was recorded. Muscle relexation was achieved with 0.1 mg kg-1 vecuronium and the patients were intubated after three minutes. The systolic, diastolic and mean blood pressure and heart rate were measured at the following times: as soon as the patient was taken into the operating room, the third minute of infusion, the third minute of induction, the first minute of intubation and the third minute of intubation. There were no significant results belonging to demographical data. The propofol requirement was significantly higher in Group C compared to the other groups (p<0.05), but the propofol dosage per kilogram values did not have any significance. Heart rate was higher in Group C at the tenth minute of infusion, the 1st and 3rd minutes after intubation in Group C compared to Groups D and E (p<0,05). Systolic and mean blood pressure values were significantly higher in Group C at the third minute after intubation compared to Groups D and E (p<0,05). There was no significant difference in diastolic blood pressure. As a result, esmolol and dexmedetomine were found to be succesfull in supressing the increase in the heart rate and blood pressure due to laryngoscopy and endotracheal intubation.