Transformation of chronic lymphocytic leukemia to mantle cell lymphoma: A case report

Akdeniz D., Balcık Ö. Ş. , Yalçın K. S. , Akyıldız Ü., Atıcı E., Güven S., ...More

Journal of Clinical and Experimental Investigations, vol.2, no.4, pp.443-445, 2011 (Other Refereed National Journals)

  • Publication Type: Article / Article
  • Volume: 2 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.5799/ahinjs.01.2011.04.0091
  • Title of Journal : Journal of Clinical and Experimental Investigations
  • Page Numbers: pp.443-445



Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clonal expansion of B lymphocytes. Richter Transformation (RT) must be considered if CLL patient had fever, weight loss, cytopenia and resistance to standard therapy. Despite CLL usually transforms to diffuse large cell lymphoma, some rare lymphomas may occur as RT such as Hodgkin variants, lymphoblastic lymphoma nad mantle cell lymphoma. Here, we report a case of Mantle cell lymphoma has become secondary to chronic lymphocytic leukemia due to its being a rare entity.