Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model

KAHVECİ, RAMAZAN; Kahveci, Fatih; Gokce, Emre; Gokce, Aysun; KISA, ÜÇLER; Sargon, Mustafa; Fesli, Ramazan; Gurer, Bora

doi:10.1016/j.wneu.2021.02.129

Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model

KAHVECİ R., Kahveci F. O. , Gokce E. C. , Gokce A., KISA Ü., Sargon M. F. , ...More

WORLD NEUROSURGERY, vol.150, 2021 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 150
Publication Date: 2021
Doi Number: 10.1016/j.wneu.2021.02.129
Title of Journal : WORLD NEUROSURGERY
Keywords: Ganoderma lucidum polysaccharides, Ischemia/reperfusion, Neuroprotection, Spinal cord, NITRIC-OXIDE SYNTHASE, ISCHEMIA/REPERFUSION INJURY, SUPEROXIDE-DISMUTASE, CELL-DEATH, PARAPLEGIA, INDUCTION, APOPTOSIS, METHYLPREDNISOLONE, EXPRESSION, PROTECTION

Abstract

OBJECTIVE: Inflammation and oxidative stress are 2 important factors in the emergence of paraplegia associated with spinal cord ischemia-reperfusion injury (SCIRI) after thoracoabdominal aortic surgery. Here it is aimed to investigate the effects of Ganoderma lucidum polysaccharide (GLPS) on SCIRI.