Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model

KAHVECİ, RAMAZAN; Kahveci, Fatih; Gokce, Emre; Gokce, Aysun; KISA, ÜÇLER; Sargon, Mustafa; Fesli, Ramazan; Gurer, Bora

doi:10.1016/j.wneu.2021.02.129

Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model

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KAHVECİ R., Kahveci F. O., Gokce E. C., Gokce A., KISA Ü., Sargon M. F., ...More

WORLD NEUROSURGERY, vol.150, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 150
Publication Date: 2021
Doi Number: 10.1016/j.wneu.2021.02.129
Journal Name: WORLD NEUROSURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Index Islamicus, MEDLINE, Veterinary Science Database
Keywords: Ganoderma lucidum polysaccharides, Ischemia/reperfusion, Neuroprotection, Spinal cord, NITRIC-OXIDE SYNTHASE, ISCHEMIA/REPERFUSION INJURY, SUPEROXIDE-DISMUTASE, CELL-DEATH, PARAPLEGIA, INDUCTION, APOPTOSIS, METHYLPREDNISOLONE, EXPRESSION, PROTECTION
Lokman Hekim University Affiliated: Yes

Abstract

OBJECTIVE: Inflammation and oxidative stress are 2 important factors in the emergence of paraplegia associated with spinal cord ischemia-reperfusion injury (SCIRI) after thoracoabdominal aortic surgery. Here it is aimed to investigate the effects of Ganoderma lucidum polysaccharide (GLPS) on SCIRI.