Sorbicillinoid-based metabolites from a sponge-derived fungus Trichoderma saturnisporum


Creative Commons License

Meng J., Cheng W., Heydari H., Wang B., Zhu K., KONUKLUGİL B. , ...More

Marine Drugs, vol.16, no.7, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 7
  • Publication Date: 2018
  • Doi Number: 10.3390/md16070226
  • Title of Journal : Marine Drugs
  • Keywords: marine fungus, Trichoderma saturnisporum, saturnispols A-H, structural elucidation, antibacterial effects, PHIALOCEPHALA SP FL30R, MARINE SPONGE, VERTICILLIUM-INTERTEXTUM, ANTIBACTERIAL ACTIVITY, DICTYONELLA-INCISA, BIOSYNTHESIS, LONGIBRACHIATUM, TRICHODIMEROL, DERIVATIVES, PRECURSOR

Abstract

© 2018 by the authors.Antibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma saturnisporum DI-IA, obtained from the marine sponge Dictyonella incisa, contained conjugated olefinic metabolites with antibacterial activity. Chemical examination of the fungal strain resulted in the isolation of eight new sorbicillinoid-based compounds, namely saturnispols A–H (1–8). Their structures were determined on the basis of extensive spectroscopic analysis, including the experimental and calculated electronic circular dichroism (ECD) data for the configurational assignments. Saturnispol F exerted significant inhibition against a panel of bacteria strains including vancomycin-resistant enterococci (VRE) with a minimum inhibitory concentrations (MIC) ranging from 1.63 to 12.9 µg/mL, while saturnispol H showed selective effects against VRE and B. subtilis.