Immediate risk of HSIL presence in women who have both ASC-US cytology and negative high-risk HPV test

Ozturk M., UMUDUM H., Aydin A., Ulubay M., Keskin U., Dede M., ...More

European Journal of Gynaecological Oncology, vol.37, no.2, pp.232-237, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.12892/ejgo2848.2016
  • Journal Name: European Journal of Gynaecological Oncology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.232-237
  • Keywords: ASC-US, Cervical cancer screening, Human papillomavirus, Human papillomavirus DNA tests
  • Lokman Hekim University Affiliated: Yes


Purpose: The authors aimed to detect immediate risk of having high grade squamous lesions (HSIL) in atypical squamous cells of uncertain significance(AS-CUS) and concomitant high-risk human papillomavirus (HrHPV) testing as negative [HrHPV(negative)AS-CUS]. Materials and Methods: The authors performed immediate/baseline colposcopy on concomitant HrHPV (negative)AS-CUS cases. Pap tests were evaluated with liquid-based cytology (LBC) and HrHPV detection was performed in LBC material with PCR. Colposcopy diagnoses and biopsy results were compared with Pap test and HrHPV test results. Results: There were 104 patients over a one-year period. In all, 84 cases were included. Colposcopic biopsies revealed low grade squamous intraepithelial lesion (LSIL) in 19 cases (23%) and HSIL in three cases (4%). Intrauterine device use and smoking were significantly correlated with presence of HSIL (p=0.005 and/?=0.007 respectively). Conclusion: Similar data in literature, 4% of ASC-US-HrHPV (negative) cases are expected to have HSIL in follow-up periods less than six months. The present authors believe clinicians should be more open with their patients about limitations of Pap-HPV testing.