An uncommon complementary isochromosome of 46,XY, i(9)(p10),i(9)(q10) in an infertile oligoasthenoteratozoospermic man


Guvendag Guven E. S. , Dilbaz S., CEYLANER S. , Acar H., Cinar O., Ozdegirmenci O., ...More

Fertility and Sterility, vol.95, no.1, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.1016/j.fertnstert.2010.05.028
  • Title of Journal : Fertility and Sterility
  • Keywords: Azoospermia, isochromosome, male infertility, nonrobertsonian translocation, TRANSLOCATION, COMPLEX, SPERMATOZOA

Abstract

Objective: To report a rare case of male infertility associated with oligoasthenoteratozoospermia and complementary isochromosome 46 XY, i(9)(p10),i(9)(q10). Design: Case report. Setting: Reference hospital. Patient(s): Infertile oligoastenozoospermic man with complementary isochromosome 46,XY, i(9)(p10),i(9)(q10). Intervention(s): Peripheral blood lymphocytes obtained for karyotyping, and florescence in situ hybridization (FISH) analysis for gonadal mosaicism in ejaculated spermatozoa. Main Outcome Measure(s): Physical examination, semen analysis, GBG banding, and FISH procedure. Result(s): The semen analysis revealed oligoasthenoteratozoospermia. The lymphocytic karyotype detected a complementary isochromosome 46,XY, i(9)(p10),i(9)(q10), and the FISH procedure showed abnormal sperm. Conclusion(s): This the first report of oligoasthenoteratozoospermia associated with complementary isochromosome 46,XY, i(9)(p10),i(9)(q10). © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.