Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper

Barbaud A., Garvey L. H., Arcolaci A., Brockow K., Mori F., Mayorga C., ...Daha Fazla

ALLERGY, cilt.77, sa.8, ss.2292-2312, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 8
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1111/all.15241
  • Dergi Adı: ALLERGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.2292-2312
  • Anahtar Kelimeler: allergy test, anaphylaxis, COVID-19 vaccine, mRNA vaccines, risk assessment, ANTI-PEG ANTIBODIES, POLYETHYLENE-GLYCOL, HYPERSENSITIVITY REACTIONS, MACROGOL HYPERSENSITIVITY, CONTACT SENSITIZATION, ANAPHYLACTIC REACTION, SAFETY, MULTICENTER, VACCINATION
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Background Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized. Method Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed. Results No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2-anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine; and 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left-over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable. Conclusions These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.