SPECTROPHOTOMETRIC DETERMINATION OF NICLOSAMIDE AND THIABENDAZOLE IN TABLETS


ONUR F., TEKIN N.

ANALYTICAL LETTERS, vol.27, no.12, pp.2291-2301, 1994 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 12
  • Publication Date: 1994
  • Doi Number: 10.1080/00032719408005983
  • Journal Name: ANALYTICAL LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2291-2301
  • Keywords: NICLOSAMIDE, THIABENDAZOLE, PHARMACEUTICAL PREPARATION, SPECTROPHOTOMETRY, LIQUID-CHROMATOGRAPHY, DRUGS
  • Lokman Hekim University Affiliated: No

Abstract

In this study, determination of niclosamide and thiabendazole in their binary mixture was realized by precipitating thiabendazole with ammonium reineckate at pH:3 selectively and reading the absorbance of the solution of the precipitate in acetone at 525.0 nm for thiabendazole and by measuring the dA/d lambda values at 405.8 nm in the first derivative spectra of the remaining solution for niclosamide. The relative standard deviation of the method was found to be 1.16 % for thiabendazole and 0.75 % for niclosamide. Recoveries were found to be 100.1 % and 98.8 % for thiabendazole and niclosamide respectively. The method has been succesfully applied to a tablet containing thiabendazole and niclosamide.