SPECTROPHOTOMETRIC DETERMINATION OF NICLOSAMIDE AND THIABENDAZOLE IN TABLETS
ANALYTICAL LETTERS, cilt.27, sa.12, ss.2291-2301, 1994 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 12
- Basım Tarihi: 1994
- Doi Numarası: 10.1080/00032719408005983
- Dergi Adı: ANALYTICAL LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2291-2301
- Anahtar Kelimeler: NICLOSAMIDE, THIABENDAZOLE, PHARMACEUTICAL PREPARATION, SPECTROPHOTOMETRY, LIQUID-CHROMATOGRAPHY, DRUGS
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
In this study, determination of niclosamide and thiabendazole in their binary mixture was realized by precipitating thiabendazole with ammonium reineckate at pH:3 selectively and reading the absorbance of the solution of the precipitate in acetone at 525.0 nm for thiabendazole and by measuring the dA/d lambda values at 405.8 nm in the first derivative spectra of the remaining solution for niclosamide. The relative standard deviation of the method was found to be 1.16 % for thiabendazole and 0.75 % for niclosamide. Recoveries were found to be 100.1 % and 98.8 % for thiabendazole and niclosamide respectively. The method has been succesfully applied to a tablet containing thiabendazole and niclosamide.