Akademik Veri Yönetim Sistemi
Journal of Neuroimmunology, cilt.316, ss.121-129, 2018 (SCI-Expanded)
© 2018 Elsevier B.V.Background Suppressors of cytokine signaling (SOCS) and brain-derived neurotrophic factor (BDNF) are important immunologic, and neurotrophic factors for MS pathogenesis. The impact of exercise on these factors is yet to be fully elucidated in patients with MS. Objective The primary aim of this study is to investigate the effect of 8-week combined exercise training on serum concentrations of SOCS1, SOCS3, and BDNF. The secondary aim is to determine the effects of combined exercise training on balance, functional exercise capacity, and fatigue in patients with MS. Methods Serum SOCS1, SOCS3, and BDNF levels were assessed in 36 MS patients and 18 healthy individuals. In addition, balance, functional exercise capacity, and fatigue were assessed in the patients with MS. The patients were randomly divided into the combined exercise group (MS-EX, n:18) and the control group (MS-C, n:18). MS-EX received an 8-week combined exercise training. Results The serum SOCS1, SOCS3, and BDNF levels were similar in the MS patients and healthy control (HC). In MS-EX, the serum BDNF level, balance, functional exercise capacity, and fatigue improved after 8 weeks (p < 0.05), but the serum SOCS1, and SOCS3 levels did not change significantly (p > 0.05). In MS-C, the serum SOCS1 level, and fatigue increased significantly after 8 weeks (p < 0.05), but serum SOCS3, BDNF, balance and functional exercise capacity did not change (p > 0.05). Conclusions In summary, the combined exercise training improved BDNF, and physical performance in patients with MS. But, future studies are needed to clarify the role of SOCS proteins in MS pathogenesis and the effect of exercise on SOCS.