Uterine contractions: an unusual side effect of venom immunotherapy.

Karakurt F., Kargili A., Bozkurt B., Kasapoglu B., Ikizek M.

Journal of investigational allergology & clinical immunology, vol.20, no.5, pp.431-2, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 5
  • Publication Date: 2010
  • Journal Name: Journal of investigational allergology & clinical immunology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.431-2
  • Keywords: Venom immunotherapy, Uterine contractions, HYMENOPTERA, ALLERGY
  • Lokman Hekim University Affiliated: No


Venom immunotherapy (VIT) is an efficient treatment modality for preventing further sting-induced anaphylactic reactions in patients with Hymenoptera venom allergy. The main side effects of VIT include local and systemic allergic reactions with a variable risk of up to 46%. We report the case of a woman who experienced rapid-onset hypocalcemia and regular uterine contractions on 3 occasions within 30 minutes of receiving Apis mellifera VIT. To the best of our knowledge, this is the first report of uterine contractions as a side effect of VIT. The importance of this event is clear, as VIT has now been approved for pregnant women. We provide recommendations to physicians using this modality.