Thiol/disulfide parameters as a novel oxidative marker in medical labor induction with oxytocin

Eryilmaz O. G., ÇELİK H., EREL Ö., Erdogan S.

Hormone Molecular Biology and Clinical Investigation, vol.29, no.2, pp.61-65, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1515/hmbci-2016-0032
  • Journal Name: Hormone Molecular Biology and Clinical Investigation
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.61-65
  • Keywords: disulfide, labor induction, oxidative stress, oxytocin, thiol, STRESS, RISK, HOMEOSTASIS, PLASMA, ASSAY
  • Lokman Hekim University Affiliated: No


© 2017 Walter de Gruyter GmbH, Berlin/Boston.The aim of this study was to analyze the alterations in thiol levels among mothers and neonates who were prone to medical oxytocin induction. A total of 40 pregnant women who underwent medical labor induction with oxytocin (Group A) were compared with 53 women whose labor progressed spontaneously without any kind of induction (Group B). We measured the thiol/disulfide homeostasis parameters (native thiol, total thiol, disulfide, disulfide/total thiol, disulfide/native thiol) of maternal and cord blood. There were no statistically significant differences with respect to the maternal and cord blood thiol/disulfide homeostasis between the two groups. Being an artificial intervention during labor, oxytocin induction has been found to be safe in terms of oxidative stress (OS) according to the results of this study. Both the maternal and the fetal sides were safe in this molecular manner against oxytocin infusion.