Thrombopoietin concentrations in the ascitic fluid and plasma of patients with chronic liver diseases

Babali A., Aksoy D. Y., HAZNEDAROĞLU İ. C., KOŞAR A., Bavbek N., Ozturk M., ...Daha Fazla

HAEMA, cilt.9, sa.2, ss.251-255, 2006 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2006
  • Dergi Adı: HAEMA
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.251-255
  • Anahtar Kelimeler: Ascites fluid, Chronic liver disease, Thrombopoietin
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Plasma thrombopoietin levels in several studies in a variety of chronic liver diseases reveal conflicting results. The place of thrombopoietin in the pathobiological basis of ascites associated with chronic liver diseases has not been elucidated. Twelve patients with chronic liver disease and thrombocytopenia (Group I) and 10 patients with chronic liver disease and normal platelet counts (Group II) were included in this study. Fifteen healthy adults served as controls. Thrombopoietin levels were assayed in ascitic fluid and plasma of the cases. There were no significant differences in age and sex between the groups. Plasma thrombopoietin levels were lower in controls compared to the patients and there was not significant difference between Group I and II. Thrombopoietin levels in ascites were significantly lower in Group I than Group II. The liver plays a central role in haematopoiesis, including thrombopoiesis as thrombopoietin is synthesized in the liver. Heterogenous liver diseases, stages and the underlying pathobiological basis and also complications are all important factors affecting thrombopoietin levels and function. Copyright © Hellenic Society of Haematology.