Two new quinoline and tris(4-hydroxycinnamoyl)spermine derivatives from Microdesmis keayana roots

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Zamble A., Hennebelle T., ŞAHPAZ S., Bailleul F.

Chemical and Pharmaceutical Bulletin, vol.55, no.4, pp.643-645, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1248/cpb.55.643
  • Journal Name: Chemical and Pharmaceutical Bulletin
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.643-645
  • Keywords: Pandaceae, Microdesmis keayana, tris(4-hydroxycinnamoyl)spermine, xanthoquininamide, VITRO ANTIPLASMODIAL ACTIVITY, PLANTS, CYTOTOXICITY
  • Lokman Hekim University Affiliated: No


Purification of a Microdesmis keayana hydromethanolic root extract led to the isolation of two new natural compounds, xanthoquininamide (6-hydroxyquinoline-4-carboxamide) and tris(4-hydroxycinnamoyl)spermine (N 5-(p-coumaroyl)-N1,N14-diferuloylspermine) which was named keayanine. Their structures were determined using spectroscopic analyses (ESI-MS, 1D- and 2D-NMR). © 2007 Pharmaceutical Society of Japan.