The effect of selenium on glutathione redox cycle enzymes of some rabbit tissues

Ulusu N., Acan N., TURAN B., Tezcan E.

Trace Elements and Electrocytes, vol.17, no.1, pp.25-29, 2000 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 1
  • Publication Date: 2000
  • Journal Name: Trace Elements and Electrocytes
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.25-29
  • Keywords: glutathione peroxidase, glutathione reductase, rabbit tissues, selenium, LIPID-PEROXIDATION, LIVER
  • Lokman Hekim University Affiliated: No


Aim: The aim of this study is to investigate the glutathione reductase and peroxidase activities of rabbit liver and brain tissues at selenium deficiency and excess. Material and method: New Zealand types of rabbits were used. While the control group was fed with normal diet, one group of animals received selenium-deficient, and another group received selenium-enriched diet for 12 weeks. Results: For both of the tissues studied, glutathione peroxidase activities of the selenium-deficient group were the same as compared to the control group. Glutathione peroxidase activities of the selenium-enriched group, however, were significantly higher than that of the control group. It was observed that liver glutathione reductase activity was lower in the selenium-deficient and higher in the selenium-enriched group with respect to the control group. For brain tissues, no significant difference among the three groups for the glutathione reductase activity was observed. Conclusion: Se deficiency and excess both causes several hazardous changes in the organism through different mechanisms. The effects of Se deficiency and excess on the glutathione redox cycle enzymes differ with respect to the source and the tissue.