Prognostic factors and clinicopathological characteristics of carcinoma of ampulla vateri


Pamukcuoglu M., Oksuzoglu B., Abali H., Akoglu M., Atalay F., Budakoglu B., ...More

International Surgery, vol.93, no.4, pp.214-219, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 93 Issue: 4
  • Publication Date: 2008
  • Journal Name: International Surgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.214-219
  • Keywords: Carcinoma of ampulla Vateri, Adjuvant therapy, Clinicopathological characteristics of carcinoma of ampulla Vateri, ADJUVANT THERAPY, PERIAMPULLARY AREA, RADICAL RESECTION, PAPILLA, PANCREATICODUODENECTOMY, SURVIVAL, PANCREAS, CANCER, TUMOR, RADIOTHERAPY
  • Lokman Hekim University Affiliated: Yes

Abstract

The aim of this study was to describe the clinicopathological characteristics and prognostic factors of carcinoma of ampulla Vateri. The medical records of 32 patients (24 men, 8 women) were evaluated. Median age was 59 years (range, 36-80 years). The performance status at the time of admission of (European Cooperative Oncology Group) 18 patients (56.3%) were ECOG-1; 8 patients (25.0%) were ECOG-2. Fifteen patients had early stage, 15 patients had locally advanced stage. Twenty-eight of 32 patients underwent curative surgery. Eleven, nine, and four patients had high-, moderate-, and low-grade histology, respectively. Fourteen patients received adjuvant treatment. Ten out of 14 patients were treated with chemotherapy. ECOG performance status (P = 0.06), stage (P = 0.05), perineural invasion (P = 0.01), tumor grade (P = 0.01), and treatment with chemotherapy, chemoradiotherapy, or only radiotherapy (P = 0.001) had a statistically significant impact on overall survival, whereas only tumor histopathology (P < 0.001) was shown to have a statistically significant effect on disease-free survival. Carcinoma of ampulla Vateri is a rare gastrointes tinal tumor. Prospective trials with larger number of patients are needed to determine the prognostic factors to help select patients for adjuvant treatment.